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Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluatefhe effect of naphthyl and methyl portion of naftifine. Compounds with 2 ,4-difluorophenyl(2a-5a) , 2,5-difluorophenyl(2b-5b) , 4-eth- ylphenyl(2c-5c), 2-hydroxyphenyl(2d-5d) and 2-methylnaphthyl(2e-5e) instead of naphthyl group with hydrogen(3a-3e), methyl(4a-4e), and ethyl(5a-5e) in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungj. Eight compounds(3a,4a,5a,3d,4d,4d,5d,3e, and 4e) showed significant anti-fungal activity against T. mentagrophytes. (E)-N-(3-Phenol-2-propenyl) -2- hydroxy-benzenemethaneamine(3d) displayed moderate antifungal activity against all five different fungi.
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